Working hard to streamline web design, Nathan Smith created the 960 Grid System: a series of electronic templates and web code to help designers create advanced sites based off the stylistic technique of the digital grid. I gave it a whirl on my recently launched (soon to be updated with more features) Bently Reserve site, and it helped me bring that site from concept to launch in 48 hours.
Ultimately, I found the Photoshop template to be a great help, and I recommend it for anyone. I didn’t care much to toy with the HTML, so I exported a transparent ping and dropped it on a div on top of my work while I coded (modern browsers can take an absolutely positioned div with a 0px point for all corners). Regardless, highly recommended for those in the know.